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Cell Death Differ 13:527528

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A 2021 systematic review in Nutrients (N=9 trials, 582 participants) confirmed that higher doses (above 300 mg/day) produced the largest reductions, reaching up to 4 mmHg systolic in hypertensive subjects [7]

Type-2 Diabetes Mellitus affects an estimated 2.3 million people, while type-I DM affects around 0.3 million ( Although complications of Diabetes Mellitus are mostly reported after years of diagnosis, impaired wound healing among Diabetes patients is the most severe and critical complication

[70] reported that high uric acid can downregulate the Nrf2/SLC7A11/GPX4 pathway to induce ferroptosis in macrophages, which is involved in the formation of atherosclerotic plaques