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Understanding the magnitude and consistency of this phenomenon across different drug classes is crucial for guiding clinical decisions, setting patient expectations, and informing long-term treatment strategies [10]

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Many gastrointestinal effects are transient, but severe, persistent, or worsening symptoms should be reported to a healthcare professional

Gastrointestinal symptoms including nausea, vomiting, and diarrhea are most common, particularly during dose escalation

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