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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)

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3d), as did treatment with other TS-targeted antifolates pemetrexed and methotrexate in colon (Extended Data Fig

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The key is recognizing the signal without overreacting

In plant polysaccharide extraction, ethanol precipitation is commonly applied to remove proteins, lipids, nucleic acids, pigments, and other small molecules from crude extracts, followed by fractionation to obtain homogeneous polysaccharides