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Carnitine thus plays a central role in the metabolism of fatty acids and energy by regulating the mitochondrial ratio of free coenzyme A to acyl-coenzyme A

Acetyl L-carnitine can help increase energy production in the mitochondria, which may boost both physical and mental energy

Studies measuring biochemical markers of muscle damage reveal that L-Carnitine reduces myoglobin levels immediately post-exercise (weighted mean difference: -11.55 ng/mL, p=0.04) and at 30-60 minutes (weighted mean difference: -41.09 ng/mL, p=0.001), as well as creatine kinase (CK) at 2 hours (weighted mean difference: -26.72 IU/L, p=0.02) and 24 hours (weighted mean difference: -48.72 IU/L, p=0.006) following exercise

Basic research supports this mechanism, demonstrating that fructose or HFD exposure induces mitochondrial structural abnormalities, mtDNA depletion, and ATP deficiency, ultimately impairing -oxidation and hepatocyte function

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