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Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons

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Three times weekly protocol Some providers transition patients to three times per week dosing once they reach steady state, which typically occurs around weeks 5 to 6

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In addition, dysregulated -KG flux from normal reductive anabolism via the TCA cycle toward R-2-HG production has been associated with other metabolic flux impairments and disrupted redox balance 119,120 (Fig