Due to ongoing interest in peptide research, many researchers seek dependable suppliers that provide products manufactured and handled according to high-quality standards
Parisa Dini 10+ years experience in pregnancy care, PCOS & women's health at DCDC
A solid 5-Amino-1MQ dosage guide for in vitro studies (cell cultures): in vitro work emphasizes careful observation
Beta-Sitosterol induces apoptosis in cancer cells through ROS -mediated mitochondrial dysregulation and p53 activation
Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome
Ovarian cancer is the sixth most common malignancy among women in developed countries and the fifth leading cause of cancer-related death, representing a complex disease associated with poor survival rates.24 The combination chemotherapy of Paclitaxel (PTX) and Carboplatin (CARB) is considered the first-line treatment regimen for ovarian cancer.25 Both agents play distinct roles in inhibiting the growth of ovarian cancer through different mechanisms,26 and they are known to exert a synergistic anti-tumor effect by activating separate apoptotic signaling pathways, thereby potentially reducing drug resistance.25 The gonadotoxic effects of platinum-based chemotherapeutic agents have been demonstrated in numerous studies, both histopathologically and in terms of follicular development.27-29 In the present study, CARB administration led to significant histopathological damage in ovarian tissue, including follicular degeneration, prominent stromal edema, congestion, hemorrhage, inflammation, and fibrosis, particularly in the medullary region
