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In general, the protective mechanism of L-theanine for the liver and kidney is to inhibit the NF-B pathway, regulate pro-inflammatory cytokines, such as IL-1, IL-6, IL-10, and TNF, and finally regulate the activities of AST, ALT, T-SOD, and other related enzymes, to effectively protect the liver and kidney and deal with liver and kidney injury caused by different reasons

Activation of HO-1 and inhibition of system Xc - (SLC3A2 and SLC7A11) provided a mechanistic explanation for this phenomenon

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The semaglutide drugs, such as Ozempic and Wegovy, target the GLP-1 pathway, which is involved in insulin secretion, appetite, and stomach emptying