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388 To confirm the role of GLP-1 in enhancing physical endurance and the possible mechanisms involved, an in vivo AAV-mediated GLP-1 overexpression model and an in vitro siRNA-mediated AMPK knockdown model were generated

doi: 10.1038/s41392-024-01931-z 16 HickeyJWBeckerWRNevinsSAHorningAPerezAEZhuCet al

''Preclinical studies indicate that GLP-1 receptor agonists reduce not just alcohol intake, but also nicotine self-administration and nicotine-related reward,'' Hendershot noted

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Bethel MA, Patel RA, Merrill P, Lokhnygina Y, Buse JB, Mentz RJ, et al

Insert the needle with firm, steady pressure at a slight angle