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One alternative repressive mechanism suggested for FBFs relies on PUF domain interaction with Argonautes resulting in attenuated translational elongation ( In several cases, PUF proteins appear to activate translation: FBFs are suggested to promote GLD-1 expression in spermatogenic germline as well as translation of EGL-4 in neurons, while PUF-8 facilitates translation of FARL-11 in germline SPCs (Kaye et al., 2009
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