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Conditions that may lead to anemia include: Heavy periods Pregnancy Ulcers Colon polyps or colon cancer Inherited disorders A diet that does not have enough iron, folic acid or vitamin B12 Blood disorders such as sickle cell anemia and thalassemia, or cancer Aplastic anemia, a condition that can be inherited or acquired G6PD deficiency, a metabolic disorder Anemia can make you feel tired, cold, dizzy, and irritable

S.GarjaniM.BararJ.et al (2016)

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Additionally, dysfunctional energy metabolism (184186) along with oxidative stress (187, 188) are also hypothesised in the development of ME/CFS