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What we care about is is it doing something in the brain or the muscles or, you know, whatever

The synovial lining in RA is dominated by synovial macrophages and FLSs, which are highly activated and produce a large number of pro-inflammatory factors, chemokines, and growth factors (52)

Local viral delivery of the IGF-I isoforms promoted muscle hypertrophy in young mice, and the effect was isoform- and age-dependent: in growing animals both IGF-IA and IGF-IB enlarged muscle, whereas in older (six-month) animals only IGF-IA produced significant hypertrophy, suggesting the bioavailability or receptor affinity of the IGF-IB isoform diminishes with age

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