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Real world pharmacovigilance database reviews have shown evidence for some psychiatric adverse effects, including insomnia with the use of some GLP-1 agonists
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Leptin binds to OB-Rb and activates the receptor-associated kinase JAK2 via transphosphorylation and phosphorylates three tyrosine residues (Y985, Y1077, and Y1138 in mice)
Safe dose titration Careful dose adjustment to minimize side effects
