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The results from figure 8 were re-plotted in Figures 9 and 10 to obtain Lineweaver-Burk and Hofstee linear plots respectively
This study shows that protofibrillar -synuclein can permeabilize vesicles, allowing the leakage of small molecules, such as dopamine, which could potentially lead to an increase in cytoplasmic dopamine levels
29% experienced side effects of the GLP-1 drugs with 3 discontinuations due to tolerability
J Biol Chem 290(38):2300923022
These alternatives avoid systemic exposure risks while maintaining or exceeding IV glutathiones limited efficacy
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If these are not sufficient, they may suggest over-the-counter options like polyethylene glycol (MiraLAX) or a stool softener after consultation
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