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The bitter taste receptor agonist quinine reduces calorie intake and increases the postprandial release of cholecystokinin in healthy subjects
They should also follow medical advice on dosage and treatment duration closely
What I love most is that it works with my body, not against it
Between these two, metformin is our first-line preference as it helps not only with antipsychotic-related weight gain but also with the metabolic side effects of antipsychotics (insulin resistance, fasting glucose, triglycerides, and hyperprolactinemia), earning it a recommendation from the APA for this purpose
Additionally, perioperative medicine does not necessarily translate to emergency medicine
However, this comes with a massive caveat that we can't stress enough: there are no large-scale, peer-reviewed human clinical trials published as of 2026 that specifically study the safety and efficacy of this exact combination
