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Furthermore, in transgenic mouse models expressing human -syn, hepatic -syn protein levels exhibit time-dependent accumulation despite the absence of -syn mRNA expression in the liver under neuron-specific promoter regulation, suggesting a potential neural system-derived origin of the protein [57]

Mice received once-daily sham injections with isotonic saline from 3 days before study start and were randomized to treatments on the basis of body weight at the day of study start

Clift Charles, Gopinathan Unni, Morel Chantal M, Outterson Kevin, Rttingen John-Arne, So Anthony, editors

Scientists are continuing to investigate its pharmacokinetics, metabolic pathways, long-term safety profile, and regulatory toxicology, but translating findings from laboratory and animal models into human applications is a significant challenge

Biopharmaceutics & Drug Disposition