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A score of 0 indicates a non-essential gene, while -1 reflects the median for essential genes

FIGURE 1 Ferroptosis is observed in mice with kidney injury, concomitant with an increase in MG levels A significant elevation in MG levels was observed in both patients and mouse models during the pathological state of kidney injury

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Additionally, therapeutic interventions that target MAPK signaling, such as the use of sakuranetin, have demonstrated efficacy in reducing eosinophilic lung inflammation and Th2/Th17 cytokine production by inhibiting the activation of ERK1/2, JNK, and p38 MAPKs [165]

Wang, Z., Masternak, M