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Once in the nucleus, NF-B regulates gene expression, activating different genes depending on its composition, with many involved in inflammation, cell growth, and differentiation

F., Pellegrino G

By hyperactivating the hypothalamic-pituitary-adrenal (HPA) axis, retinoic acid, the active form of vitamin A, has been related to depressed behavior

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In subgroup analyses, a significant interaction was observed with age ( p for interaction = 0.028), with a more pronounced risk increase among older adults (65 years) (HR 1.15