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These changes to normal gastrointestinal physiology explain why diarrhea (defined as three or more loose or watery stools per day) and other gastrointestinal symptomsincluding nausea, vomiting, constipation, and abdominal painare among the most frequently reported side effects

Enhancing bioavailability of noradrenaline or adrenergic responsiveness of astrocytes could be a valid therapeutic strategy

Ishii, J

While prior reviews have broadly addressed heat stroke pathophysiology, this article uniquely synthesizes cell death mechanisms (apoptosis, pyroptosis, ferroptosis) as central drivers of heat stress-induced liver injury and critically evaluates their implications for targeted therapeutic development

however, higher doses resulted in an insignificant increase in bleeding events

P-5-P is the biologically active coenzyme required for the transsulfuration pathway, the specific biochemical route the body uses to convert homocysteine into endogenous cysteine