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Taken together, these findings indicated that hepsin / mice experience heightened oxidative stress in the early stages of APAP exposure, suggesting that endogenous hepsin might protect against toxicity during the early stages of APAP exposure, thereby significantly influencing survival outcomes in drug-induced toxicity cases

Diabetes Obes Metab 22:11761186

However, treatment with nicotinamide a class III HDAC inhibitor, though induced histone hyperacetylation and overexpression of neurotrophic factors but failed to provide neuroprotection

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