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Genetic influence is particularly strong with restricted/repetitive behaviors and hyperactivity/impulsivity

This highlights the role of GSTP1 as an oxidative stress sensor, adjusting JNK signaling pathways based on the level of reactive oxygen species to promote either cell survival or apoptosis

Not suitable for use during pregnancy or while breastfeeding

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With GSH depleted, IKK becomes constitutively active, driving continuous transcription of TNF-, IL-6, and IL-1

However, most available evidence is derived from in vitro studies, and the reported mechanisms largely reflect downstream signaling and biomarker changes under experimental conditions