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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

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If you have symptoms like fatigue, brain fog, or nerve pain plus suboptimal B12 levels, a trial of supplementation is worth trying since it's very safe

Typically, vitamin B12 injections can be effective for about one week

Bibcode:2012ApEnM..78.8025R