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Corvillo F, Ceccarini G, Nozal P, et al

The most rapid reduction occurs during the first 2028 weeks of treatment, with the rate of loss gradually slowing thereafter

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CASTA, the Cerebrolysin Acute Stroke Treatment in Asia trial, randomized 1,070 patients within twelve hours of an ischemic stroke to either 30 mL of cerebrolysin a day for ten days on top of aspirin, or to a saline placebo (Heiss et al., Stroke 2012, phase 3)