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The preserved muscle mass also means better glucose control and insulin sensitivity, enhancing the metabolic benefits of the GLP-1 medications

doi: 10.1016/j.phrs.2022.106320

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Structural tissue-level changes develop over 612 weeks

Studies have shown that antidiabetic drugs such as pioglitazone significantly reduce the enzyme activity of skeletal muscle TNF- and TACE and improve the mitochondrial proteomic profile of skeletal muscle in subjects with T2D [68]