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In 1891, it was found to be useful to treat malaria, thus making methylene blue "the first synthetic compound ever used as an antiseptic in clinical therapy and the first antiseptic dye to be used therapeutically," according to the authors of a Medicinal Research Reviews paper on the compound

(PubMed) Sandstead HH, Frederickson CJ, Penland JG

High-concentration rapid transients of glutamate mediate neural-glial communication via ectopic release

It can, but it does not have to

Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig

There are over 100,000 glutathione citations on PubMed, and research continues worldwide