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Each participant donated a venous blood sample, an overnight urine sample, and a fecal sample for microbiome analysis at baseline before treatment initiation, after 1 month, 3 months, and 12 months of treatment

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Gastroenterol., 2007

98 The reasons behind the discordant results in the cardiovascular outcomes in the use of GLP-1R agonists in humans with T2DM are likely multifactorial, including heterogeneity in disease, patient population and treatment regimens, and a lack of bioequivalence among the agents

Medications such as metformin or SGLT2 inhibitors, when indicated for glycaemic control, may have modest weight-neutral or weight-reducing effects

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