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#Semaglutide: Just Another Off-Patent Generic

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Weight-loss injections Weight-loss injections particularly GLP-1 receptor agonists like tirzepatide and semaglutide have rapidly become the most effective FDA-approved pharmacological option for chronic weight management

The authors note: In conclusion, initiation of GLP-1RA therapy, compared with other active antidiabetic treatments, was associated with a small but statistically significant increase in fracture risk among older adults with type 2 diabetes. Why Might GLP-1 Drugs Affect Bone Density

Zerbini G, Bonfanti R, Meschi F et al (2006) Persistent renal hypertrophy and faster decline of glomerular filtration rate precede the development of microalbuminuria in type 1 diabetes

In trials with semaglutide was added on to insulin with or without metformin, severe hypoglycemia was reported in 1% of patients receiving the 14 mg tablets, 1% of patients receiving placebo, and 0% of the patients receiving the 7 mg tablets