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Additional exclusion considerations in clinical research design: Severe renal impairment (eGFR below 30 mL/min/1.73m2)

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HT-1080 Control N -treated with DMSO or nutlin-3b: 1,0001,500, MDM2 inhibitors: 3,0004,000, or gemcitabine: 3,0004,000

[39] In a normal person at therapeutic doses, this effect is usually not noticeable, but when respiration is already compromised, it may be evident