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Opposite effects of low and high doses of A42 on electrical network and neuronal excitability in the rat prefrontal cortex

Coskun T, Heise T, DeVries J et al (2022) Tirzepatide reduces appetite, energy intake and fat mass in people with type 2 diabetes

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Dosing Guidelines: 100-500mcg 1-3x/day for a 12-week cycle

Its cognition-enhancing effects may be due to an ability to influence the brains levels of noradrenaline, serotonin, and dopamine,4 three neurotransmitters with well-documented relationships to vigilance, attention, learning,5 memory,6 and the motivation toward cognitive effort.7 Meanwhile, its anxiolytic effects appear to be GABAergic (i.e., relating to the neurotransmitter GABA)

HGF, upon binding to its receptor, encoded by the proto-oncogene MET (Naldini et al., 1991), elicits relevant biological activities, including cell motility, division, survival, and differentiation (Trusolino et al., 2010)