Melanoacanthoma Melanoacanthoma is a rare form of benign melanotic lesion characterized by benign proliferation of both keratinocytes and melanocytes (63)
Clinically, oral pigmentations can range from a solitary macule to large patches and broad, diffuse tumefactions
Common ones include nausea, diarrhea, and decreased appetite
For example, in the liver affected by NAPQI, severity of injury may range from full necrosis in hepatocytes immediately around the central vein, to cells in the midzonal region that still survive, but have undergone adaptive responses as they continue to experience persistent JNK activation and oxidant stress, but have not yet reached an irreversible sustained MPT, to periportal hepatocytes that are minimally affected or undergoing successful repair
Acta Neuropathol.2017;134:61928
Top sets feel steadier under heavy loads