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Li et al demonstrated that vitamin B12 may up-regulated insulin like growth factor-1 (IGF-1) gene expression, and showed a better neuroprotective effect in the presence of good control of hyperglycemia in rats with diabetic peripheral neuropathy 20

A metanalysis published in 2016 explored the benefit of selenium supplementation in HT

Vitamin D also has a significant function in regulating central and blood serotonin concentration by controlling the transcription of TPH 1 and TPH 2 genes [26]

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