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further confirmed that hypoxia participates in the pathogenesis of MS by modulating EndoMT-related genes, potentially involving transforming growth factor- (TGF-), NF-B, TNF, and mTOR signaling pathways (171)

[33] [34] Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland

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doi: 10.1016/S1470-2045(20)30494-0

Additionally, OA severity and inflammatory biomarker levels correlate with increased Fusobacterium abundance, elevated Faecalibacterium prausnitzii levels, and decreased Ruminococcaceae family representation in the gut microbiota (Gaspar et al., 2025

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