does tirzepatide cause kidney problems In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization for heart failure or all-cause mortality vs sitagliptin, but offered no additional benefit over semaglutide. https://ja.ma/3JO2SQc Diabetic cardiorenal injury and preventive

Am J Physiol Endocrinol Metab 292(2):E543-548

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These landmark studies established that GLP-1 medications deliver clinically significant results in non-diabetic populations, leading to FDA recognition of semaglutide and tirzepatide as weight loss agents independent of diabetes status

successfully prolonged the duration of insulins action by acylating insulin at LysB29, which allowed this peptide hormone to bind with endogenous serum proteins

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