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Less common causes of chest pain include: A blockage in a major artery of your lungs (pulmonary embolism) An enlarged or thickened heart (hypertrophic cardiomyopathy) Narrowing of a valve in the main part of your heart (aortic stenosis) Swelling of the sac around your heart (pericarditis) Tearing in the wall of your aorta, the largest artery in your body (aortic dissection) What Are the Risk Factors for Angina

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