If you could choose, do you want to be hit by a freight train or a minivan? Spangler said, adding that when it comes to smoking just one cigarette a day, Yes, it is less risky, but its still very risky. If a patient says to me, I want to quit smoking 20 cigarettes a day, but I think I can only cut down to one [cigarette] a day, I tell them that there is some harm reduction, Spangler said
Also, nicotine interrupts the airway epitheliums barrier function, leading to the release of inflammatory proteins into the systemic circulation and causes multi-organ fibrosis [101]
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