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Identifying novel therapeutic targets within the melatonergic system and circadian clock machinery could lead to the development of more specific and potent interventions for nicotine dependence

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Systematic reviews of school-based smoking prevention curricula have found that some programmes, particularly those emphasising social competence or combining social competence with social influence approaches, are associated with modest but statistically significant reductions in smoking initiation compared with no programme, although overall effect sizes are small and study quality is mixed

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