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The human brain continues to develop until approximately age 25, and exposure to nicotine during adolescence can significantly harm this ongoing development, particularly impacting areas responsible for attention, learning, mood regulation, and impulse control [22, 24]

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Moreover, if p53 / mice suffer from acute liver failure, the liver injury of mice will be prolonged, and the initiation of liver regeneration will be delayed than that in wild type 23

Interestingly, while all grades experienced a significant decline in cigarette use, 12th graders consistently reported the highest percentage of occasional smokers compared to the other school grades, even in 2021

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