The oil-soluble format ensures compatibility with lipid-based formulations
The experimental evidence also has degrees of strength and is often debatable and controversial, especially where results from studies using isolated chemicals on cells and animals in the lab are extrapolated to humans
Other harmful volatile chemicals have acute effects, such as carbon monoxide, which displaces oxygen from hemoglobin in blood
To me, it has a bit more of a masculine smell, but it could still be unisex as well
So, while technically true in cells in culture, in intact humans, there is no evidence that this is a concern, and nicotine is not considered a carcinogen
1 When the plant is harvested for manufacturing, these chemicals are present in the tobacco leaves