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For the purpose of this discussion, we will focus on substances that are commonly referred to as gateway drugs: caffeine alcohol tobacco marijuana Caffeine Image 4.2 Hot Coffee in a White Mug Surrounded by Coffee Beans on a Wood Table History and Background Caffeine is a bitter substance that occurs naturally in more than 60 plants, including coffee beans, tea leaves, kola nuts (used to flavor soft-drink colas), and cacao pods (used to make chocolate products)