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Nicotine crosses the placenta which leads to significant placental damage, contributing to fetal growth and low birth weight

Linneberg A, Simonsen JB, Petersen J, Stensballe LG, Benn CS (2006) Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology

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2000 Tobacco Control 9 : 136147 Pollay RW, Dewhirst T

Therefore, nicotine exposure during this critical period can lead to profound and rapid neuroadaptations in the brains reward pathways, specifically by influencing the dopamine and nicotinic acetylcholine receptors (nAChRs), increasing the susceptibility to addiction and decreasing the ability to control cravings 22

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