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Based on the results of this study and the effective anti-inflammatory mechanism of nicotine, we suggest that current smokers should use nicotine replacement therapy during hospitalization due to COVID-19 to avoid further damage caused by the storm of inflammatory factors

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Many (but not all) countries experiences of patterns of tobacco use fit this model

In summary, we found dysregulated HIF signaling in CSE-treated cells under normoxic conditions, which also had functional implications for ARPE-19 cells as not only OXPHOS but also glycolysis was impaired