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As it enters the respiratory tract, the smokes acidic compounds can contribute to acid reflux since they weaken the lower esophageal sphincter

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Indeed, while nicotine in normal doses is not as dangerous as perceived, the Surgeon Generals report in 2014, The Health Consequences of Smoking50 Years of Progress, surmised that nicotine has acute toxicity at high doses and activates biological pathways that upsurge the risk of disease

Materials and Methods We collected data on the smoking experiences of participants aged 2039 years who underwent biannual examinations provided by the Korean National Health Screening Program from 2009 to 2012