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In contrast, as food chemists Andreaa Claudia Toma, Simone Stegmller, and Elke Richling write, European regulators have adopted a more measured approach, recommending a tolerable daily intake (TDI) of 0.1 milligrams of coumarin per kilogram of body weight as a conservative limit to minimize the health risks

By combining a human and an animal study, Kuntic et al 15 demonstrated that e-cigarette aerosol induces vascular, cerebral, and pulmonary oxidative stress, inflammation, and an increase in blood pressure in exposed mice

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