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Product-related factors include: Cigarette pack design and filter structure Perforated cigarette papers that affect airflow Tobacco blend density and composition User-related factors include: Puffing habits and puffing regimes Inhalation depth Smoking frequency These variables directly influence nicotine absorption rate and overall nicotine exposure

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Further, these findings are plausible in light of historic tobacco industry marketing of menthol cigarettes as medicinal, less harmful, or even a more healthful product than non-menthol cigarettes [103,104,105,106] and the resulting perceptions among menthol smokers that menthol cigarettes may be less risky than regular cigarettes [107]