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ACh signaling could be affected by exposure causing aberrant desensitization of the nAChR overexpression, resulting changes in cholinergic signalings amplitude [54]

Additionally, third-hand smoke is formed when residue from secondhand smoke accumulates in environments where tobacco has been smoked, ultimately polluting landfills and leaching into groundwater

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This had advantages from a clinical point of view (generating data of great detail and depth) but came at the cost of generalizability across healers or cultures

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26,27 The promotion of these novel products as a safer alternative to cigarettes has created a chasm in the public health community that has served the tobacco industry well