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For someone who smokes 20 cigarettes a day, this amounts to a daily nicotine intake of 20 to 40 milligrams, which can contribute to nicotine dependence

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The result is a profile that feels lighter, fresher, and more controlled, while still maintaining a stable tobacco structure underneath

Notably, serum cotinine levels differed significantly across sex, age categories, race/ethnicity, educational attainment, household income, BMI, alcohol consumption, physical activity, diabetes, periodontitis status, and smoking status