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Otherwise, NE increased superoxide production in human peripheral blood mononuclear cells via NOX activation and ROS production ( 3.5 RAAS and immune system ANG-II can cause dysregulations of the adaptive immune system through the stimulation of macrophages and other immune cells mediated by signalling through AT1R ( via AT1R in various cell types, such as the kidney, vasculature, and central nervous system, resulting in an inflammatory immune response ( 3.6 RAAS and insulin resistance ANG II causes hyperinsulinemia and insulin resistance (Zhou et al., 2012
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To achieve early detection, early diagnosis, and early treatment, the combination of HRCT and PRM has been shown to differentiate functional small airway disease (fSAD) from emphysema at the voxel level and predict subsequent functional and structural progression
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