Psychiatric issues, such as depression, anxiety, and psychosis
Ars Technica
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ASHRAE stated, E-cigarettes do not produce a vapor (gas), but rather a dense visible aerosol of liquid sub-micron droplets consisting of glycols, nicotine, and other chemicals, some of which are carcinogenic (e.g., formaldehyde, metals like cadmium, lead, & nickel, and nitrosamines, 17 and also updated its international ventilation standard for acceptable indoor air quality based on an environment free of tobacco cigarette smoke, secondhand aerosol from ESDs, and marijuana
The lack of any real unifying theme beyond awkward conversational pauses amidst the smoke and caffeine force the viewer to provide the context that Jarmusch hasn't bothered to provide
The two regularly updated studies on the global death toll from tobacco use published respectively by the World Health Organization and the Institute for Health Metrics and Evaluation agree that around 8 million people die prematurely every year from tobacco use