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The role of nicotine in tobacco harm reduction By Grant Churchill As a pharmacologist, I remain perplexed that most people, including scientists and doctors, are under the misconception that the harms of tobacco come from nicotine

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By extension, one can infer minimal or no harm with nicotine use

The average cigarette contains upward of 600 different ingredients on top of over 7,000 chemicals produced by cigarette smoke

PMI applied for both, but the FDA decided only to grant the exposure modification