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It is characterized by a problematic pattern of tobacco use leading to clinically significant impairment or distress

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[30] Commercialization and Mass Production: Technological advancements, particularly the introduction of steam-powered machinery, allowed for large-scale commercial production of tobacco products, making them more accessible and affordable

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Structural Changes in the Adolescent Brain The structural changes in the adolescent brain include prolonged reorganization of gray matter, white matter, and associated neurochemical systems