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Other questions remain about the long-term safety of e-cigarettes

In 2018, smoking had an estimated economic impact of $600 billion, including more than $240 billion in health care spending

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Healthcare providers use this measure to tailor smoking cessation programs

By estimating the number of puffs per milliliter and the nicotine content per puff, users can determine their nicotine intake and compare it to smoking traditional cigarettes more accurately

The resulting trend lines are used to derive estimates for single years, so that a number can be reported even if the country did not run a survey in that year